Intravenous acetaminophen (at 15 mg/kg/dose every 6 hours) in critically ill preterm neonates with patent ductus arteriosus: A prospective study. Acetaminophen has been increasingly used in treating patent ductus arteriosus (PDA) in preterm neonates. The authors treated 55 preterm neonates (≤37 weeks’ gestation) with haemodynamically significant PDA with intravenous acetaminophen administered at 15 mg/kg/dose every 6 hours. They monitored serum concentrations, and performed echocardiographic monitoring, and serial liver and renal function tests. Forty-three (78.2%) neonates had successful closure of the ductus arteriosus. Toxicity was less frequent than other drugs; 10 had elevated alanine aminotransferase; 8 had altered renal function tests indicating AKI. No association was observed between the serum acetaminophen concentrations and PDA closure.
Balloon Valvuloplasty via the Pulmonary Artery Trunk for Treating Neonates With Severe Pulmonary Valve Disease. Percutaneous balloon pulmonary valvuloplasty is frequently used in neonates with severe pulmonary valve disease. However, peripheral vessel injury, tricuspid chordae tendineae rupture, and cardiac tamponade could occur. The authors describe their experience with balloon valvuloplasty through pulmonary artery trunk. They made a 2-cm parasternal incision in the left 3rd intercostal space, and inserted and advanced a guidewire to perforate the pulmonary valve from the pulmonary artery trunk into the right ventricle, followed by balloon dilation of the valve. The procedure has been successful in a pilot cohort. The oxygen saturation increased immediately after the balloon dilation, while the right ventricular systolic pressure and the gradient across the pulmonary valve decreased. No severe complications occurred. It seems to be a safe procedure, which merits further evaluation.
Early detection of significant congenital heart disease: The contribution of fetal cardiac ultrasound and newborn pulse oximetry screening. Fetal cardiac and newborn pulse oximetry has facilitated early detection of cardiac abnormalities. Prenatal diagnosis of fetal cardiac abnormalities allows the obstetrician to organise safer in-utero transfer of the fetus for delivery at a tertiary centre. Similarly, newborn pulse oximetry alerts the paediatrician about a need for evaluation prior to discharge. The authors present a brief synopsis of the clinical findings that may point to a cardiac abnormality and the accuracy of prenatal and newborn pulse oximetry screening.
Editorial team (being constituted) includes:: Drs. Gayatri Jape, Mariam, Rani Bashir
Last edited: April 11, 2021
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