Better maternal quality of life in pregnancy yields better offspring respiratory outcomes: a birth cohort. The authors performed a multi-center, observational study with 72,685 participants to examine whether maternal factors during pregnancy leads to offspring's risk of allergic disorders at 3 years of age. They show that poor maternal prenatal quality of life/anxiety-depression increased the risk of wheeze, asthma, and food allergy in offspring.
A systematic review of neurogenesis in animal models of early brain damage. Implications for cerebral palsy Brain damage during early life is the main factor in the development of cerebral palsy (CP), which is one of the leading neurodevelopmental disorders in childhood. The authors conducted a systematic review of preclinical evidence of structural neurogenesis in early brain damage and pathogenesis of CP. After screening 29 studies with 751 animals, they have noted important changes based on the timing of the insult; prenatal brain damage may impact neurogenesis and curb generation of neural stem cells, while postnatal injury may increase the proliferation of neural precursor cells, alter neuronal migration, and reduce the survival of new neurons.
First trimester employment, working conditions and preterm birth: a prospective population-based cohort study. The authors studied 7561women for the impact of working conditions during first trimester and total preterm birth (PTB). They have noted that prolonged standing/walking during first trimester was associated with an increased risk of preterm birth, mainly related to secondary medical (iatrogenic) causes (odds ratio =2.09). The highest risk was found for the combination of a long workweek with high physical workload (odds ratio =3.42).
Prenatal progesterone and long term neurodevelopment, behavior and health. This systematic review included five RCTs, with 4222 measurements on children between the ages of 6 months-8 years. All studies compared progesterone to placebo in second ± third trimester for preterm birth prevention. The authors concluded that there was no evidence of benefit or harm in offspring prenatally exposed to progesterone treatment. Further longer term follow up studies are recommended.
Does early intervention (EI) reduce parental stress after preterm birth? This meta-analysis aimed to identify the effect of EI programs on decreasing parental stress due to preterm birth of their babies. 15 RCTs were included. Domains commonly reported included: Childcare related stress (Child domain), personal discomfort (parent domain) and computation of both (Total stress). The authors concluded that EI programmes reduced parental stress significantly at 18 months and 5 years.
Updated by Dr. Gayatri Jape, Perth, May 2021
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