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Antenatal corticosteroid therapy in late preterm delivery: a nationwide population-based retrospective study in Taiwan. The authors performed a population-based retrospective study (2004-2011) to investigate whether antenatal corticosteroid therapy improves neonatal and maternal outcomes in late preterm delivery. The outcomes of 5,745 women treated with corticosteroids between 34 weeks 0 days and 36 weeks 6 days of gestation were compared with those of 28,135 untreated controls. The outcome measures were neonatal outcomes, maternal outcomes, and the utilisation of healthcare services. Births from steroid-treated women showed less need for continuous positive airway pressure, the number of neonatal intensive care unit admission, and the need for glucose administration as well as the risk of neonatal respiratory distress, but increased the risk of neonatal sepsis and the number of outpatient visits.
Post-extubation noninvasive ventilation in respiratory distress syndrome: A randomized controlled trial. The authors studied 120 preterm neonates to compare 3 modalities of post-extubation respiratory support - noninvasive positive pressure ventilation (NIPPV), nasal bi-level positive airway pressure (N-BiPAP), and nasal continuous positive airway pressure (NCPAP). The outcome measures were respiratory failure within 48 hours after extubation, total days of invasive and noninvasive ventilation, duration of hospitalization, and mortality. The three groups did not differ in post-extubation respiratory failure or the number of days of ventilation. N-BiPAP was associated with longer durations of mechanical ventilation and hospitalization. However, the 3 modalities did not differ in the rate of extubation failure. Gestational age and birth weight were shown to predict successful extubation.
HFOV vs CMV for neonates with moderate-to-severe perinatal onset acute respiratory distress syndrome (NARDS): a propensity score analysis. This retrospective study evaluated whether high-frequency oscillatory ventilation (HFOV) could reduce mortality and/or bronchopulmonary dysplasia (BPD) in infants with respiratory distress syndrome (RDS) compared with conventional mechanical ventilation (CMV). Among the 700 neonates with RDS, 501 (71.6%) received CMV, while 199 (28.4%) received HFOV. The results showed that birth weight and oxygenation index (OI) were independently associated with mortality. There was no difference in mortality or BPD.
Editorial team (being constituted) includes: Dr. Apoorva Tangri (USA)
Last edited: April 11, 2021